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Digestion: Colitis, esophagitis, gastrointestinal hemorrhage, gum hemorrhage, hepatitis, increased salivation, digestive tract opening, liver damages, pancreatitis, tummy abscess, and stool abnormality.



Hemic and also Lymphatic: Anemia, leukocytosis, leukopenia, thrombocytopenia, lymphadenopathy, and pancytopenia. Altered PT and/or INR, rarely connected with hemorrhagic or thrombotic difficulties, were noted when bupropion was coadministered with warfarin.



Stressed System: Abnormal (EEG), aggression, akinesia, aphasia, coma, completed suicide, delirium, misconceptions, dysarthria, dyskinesia, dystonia, bliss, extrapyramidal disorder, visions, hypokinesia, enhanced sexual libido, manic reaction, neuralgia, neuropathy, overly suspicious ideation, restlessness, suicide effort, and also unmasking tardive dyskinesia.



Urogenital: Abnormal ejaculation, cystitis, dyspareunia, dysuria, gynecomastia, menopause, uncomfortable erection, prostate problem, salpingitis, urinary incontinence, urinary system retention, urinary system tract problem, and vaginitis.



Bupropion is mainly metabolized to hydroxybupropion by CYP2B6. The potential exists for medicine communications between Zyban and medicines that are inhibitors or inducers of CYP2B6.



Preventions of CYP2B6: Ticlopidine and Clopidogrel: Concomitant treatment regarding these medicines can enhance bupropion exposure however decline hydroxybupropion exposure. Based on scientific feedback, dosage adjustment of Zyban may be needed when coadministered regarding CYP2B6 preventions (e. g. ticlopidine or clopidogrel) [see Clinical Pharmacology (12.



Inducers of CYP2B6: Ritonavir, Lopinavir, as well as Efavirenz: Concomitant therapy regarding these drugs could lower bupropion as well as hydroxybupropion exposure. Dose rise of Zyban may be necessary when coadministered regarding ritonavir, efavirenz, or lopinavir [ see Clinical Pharmacology (12.3)] however ought to not go beyond the optimum recommended dosage.



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